The researchers successfully demonstrated the efficacy of adeno-associated virus (AAV) therapy.
AAV is not a new therapy; in fact, it has been tested in neonatal animals. “Despite having already rescued hearing in neonatal animals with genetic defects, the vectors have yet to demonstrate this ability in fully mature or aged animal models,” reveals theIn this new study, the team went on test the efficacy of AAV in aged animal models. They tweaked an aged mouse model with a hearing loss mutation similar to a "defective" TMPRSS3 gene, which causes this problem in humans.
“Our findings suggest that a virally mediated gene therapy, either by itself or in combination with a cochlear implant, could potentially treat genetic hearing loss. This was also the first study that has rescued hearing in aging mice, which points to the feasibility of treating DFNB8 patients with DFNB8 even at an advanced age. The study also establishes the feasibility of other gene therapies in the aged population,” said Zheng Yi Chen, D.Phil.
This new study paves the way for the development of clinical treatments for the elderly population, which could eventually reverse hearing loss to some extent.
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