It says experimental pill Amycretin was safe and tolerable for patients in an early-stage trial, with mild-to-moderate side effects.
Already a subscriber?Ozempic maker Novo Nordisk says its highly anticipated experimental weight-loss pill Amycretin was safe and tolerable for patients in an early-stage trial, with mild-to-moderate side effects., said in March that a phase-one trial of the pill version of Amycretin showed participants lost up to 13.1 per cent of their weight after 12 weeks. That compared to weight loss of about 6 per cent after 12 weeks and 15 per cent after 68 weeks in trials of Wegovy.
“What we see in the study period is a 13.1 per cent weight loss with a side-effect profile comparable to what we normally see with incretin-based therapy, so primarily gastrointestinal side effects,” Martin Holst Lange, Novo’s head of development, said. In the Amycretin trial, the side effects were related to gastrointestinal discomfort, including nausea and vomiting, similar to those seen in trials of its other medicines from the sameNovo is also developing another two-drug combination known as CagriSema, which also targets the amylin hormone, and which the company has said has a potential of up to 25 per cent weight loss.
In the study, overweight or obese patients without diabetes received increasing doses of Amycretin, starting from 3 milligrams and up to a final dose of two 50mg pills, Novo said.
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