The pharmaceutical giant said it would now trial a three-dose regimen for children under five after early studies suggested that two doses wasn’t enough.
Pfizer is changing plans and testing three doses of its COVID-19 vaccine in babies and preschoolers after the usual two shots regimen didn’t appear strong enough to provide immunity for some of the children.
It’s disappointing news for families anxious to vaccinate their toddlers. Pfizer had expected data on how well the vaccines were working in children under 5 by year’s end, and it’s not clear how long the change will delay a final answer. A kid-sized version of Pfizer’s vaccine already is available for 5- to 11-year-olds, one that’s a third of the dose given to everyone else 12 and older.
The very low-dose shots appeared to work in youngsters under age 2, who produced similar antibody levels. But the immune response in 2- to 4-year-olds was lower than the study required, Pfizer vaccine research chief Kathrin Jansen said Friday in a call with investors.Rather than trying a higher-dose shot for the preschoolers, Pfizer decided to expand the study to evaluate three of the very low-dose shots in all the study participants — from 6 months up to age 5.
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