Campus Innovation Award (CIA)-funded project evaluated lead compounds predicted to bind a pro-inflammatory protein discovered by PlaqueTec
From PlaqueTecMay 14 2024Reviewed by Danielle Ellis, B.Sc. PlaqueTec, a company identifying endotype-specific biomarkers to advance precision medicine for coronary artery disease , based at the Babraham Research Campus, and the Welch research group at the Babraham Institute today announced the successful completion of a collaboration to evaluate lead compounds predicted to bind a pro-inflammatory protein discovered by PlaqueTec in pilot studies.
PlaqueTec and the Welch research group, focused on research into cell signalling and led by Dr Heidi Welch, tested the pro-inflammatory protein in a human cell culture model, demonstrating its potential to be targeted by small molecule drugs—opening new opportunities for a precision medicine approach to heart disease. The target is now being evaluated as part of PlaqueTec’s ongoing BIOPATTERN trial and, if validated, further development will be pursued.
Dr Heidi Welch, Associate Group Leader, Signalling Research Programme at the Babraham Institute, added: “Our work is focused on the molecular mechanisms that control a specific family of proteins, particularly in inflammatory cells, and we are delighted to have leveraged this expertise in an early phase target discovery and development project with PlaqueTec for its recently discovered pro-inflammatory protein target.
Coronary Artery Disease Drugs Medicine Molecule Precision Medicine Protein Research
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