Patients who take blockbuster drugs like Wegovy or Ozempic for weight loss may face life-threatening complications if they need surgery or other procedures that require empty stomachs for anesthesi…
may face life-threatening complications if they need surgery or other procedures that require empty stomachs for anesthesia.Some anesthesiologists in the US and Canada say they’ve seen growing numbers of patients on the weight-loss drugs who inhaled food and liquid into their lungs while sedated because their stomachs were still full — even after following standard instructions to stop eating for six to eight hours in advance.
The drugs induce weight loss by mimicking the actions of hormones, found primarily in the gut, that kick in after people eat. That accounts for how long semaglutide, the active medication in Wegovy, remains in the body, said Dr. Philip Jones, a Mayo Clinic anesthesiologist who is also deputy editor-in-chief of the journal.“When 90% of it is gone, which is after three weeks, hopefully everything should go back to normal,” Jones said.
, a 42-year-old man in Boston who recently began taking Wegovy, had to be intubated and suffered respiratory failure that put him in intensive care.The drugs can slow digestion so much that it puts patients at increased risk for pulmonary aspiration. on a low dose of Ozempic had fasted for 10 hours before a routine endoscopy prior to bariatric surgery last fall.
Hobai is completing a retrospective study of almost 200 patients taking semaglutide. While it’ll be published later this year, the work so far appears to confirmIn that study, about a quarter of patients taking semaglutide had residual food in their stomachs during procedures requiring sedation — even after stopping the drug for 10 days.
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