Scripps Research scientists have found that LY2444296-;a compound that selectively blocks the kappa opioid receptor (KOP)-;may reduce drinking in cases of alcohol dependence in animal studies.
Mar 29 2024Scripps Research Institute Scripps Research scientists have found that LY2444296-;a compound that selectively blocks the kappa opioid receptor -;may reduce drinking in cases of alcohol dependence in animal studies. The findings, which were published March 9, 2024, in Scientific Reports, could eventually inform new treatment options for people who experience alcohol use disorder .
For their study, Martin-Fardon and Flores-Ramirez sought to find out whether orally administering LY2444296 could decrease alcohol consumption in rats that formed alcohol dependency. The aim was to mitigate withdrawal symptoms, which would hypothetically lead to reduced alcohol intake. Once rats received LY2444296 at doses as low as 3 mg per kg following 8 hours of abstinence-;when acute withdrawal symptoms typically start-; withdrawal signs and alcohol consumption tapered down significantly.
Related Stories"People drink to get rid of the sensations of withdrawal," Martin-Fardon says. He added that withdrawal is associated with physical pain, and that oftentimes, "the only thing that can fix the problem is to have a drink." But if LY2444296 is taken before withdrawal symptoms begin, "you can decrease the symptoms, so you feel better and drink less."
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