A new cancer treatment system Photodynamic therapy, which uses photo-uncaging systems to activate a cancer-fighting agent in situ at the tumor, is one method of treating cancer. However, suitable agents must be visible light stable, have an anti-tumor effect in low-oxygen settings, and be triggered
Researchers from The Institute of Industrial Science, The University of Tokyo have developed a streamlined photo-uncaging system for photodynamic cancer therapy, using a pulse of light for tumor-specific activation of a cancer-fighting agent. Credit: Institute of Industrial Science, The University of TokyoPhotodynamic therapy, which uses photo-uncaging systems to activate a cancer-fighting agentat the tumor, is one method of treating cancer.
They uncage alkyl radicals, which are known to be capable of inducing cell death both with and without the presence of oxygen. Alkyl radicals are converted into terminal aldehydes in the presence of oxygen, and these terminal aldehydes can also induce cell death. The team used molecules called “organorhodium phthalocyanine complexes” to develop, for the first time, a novel platform for photo-uncaging therapy.
They went on to show that the compounds that were released after the organorhodium phthalocyanine complexes were activated showed toxicity to HeLa cells, a cell line developed from cancer, indicating that these compounds would have the ability to fight cancer if released inside a tumor.
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