Real-time, volumetric imaging of radiation dose delivery deep into the liver during cancer treatment
. To further improve the system sensitivity and add the volumetric imaging capability, the iRAI detector and amplification components were thoroughly redesigned to achieve real-time 3D imaging of deposited dose during RT. In this system, the radiation acoustic signals were detected by a custom-designed 2D planar matrix array with 32 × 32 = 1,024 elements, 3.45 × 3.45 mm element dimension and 0.2 mm kerf. The central frequency of 0.
During the experiment, anesthesia was induced using ketamine via intramuscular injection and maintained with 1.5% isoflurane and oxygen using a V-Gel and Matrx vaporizer . Vitals were continuously monitored using a SurgiVet Advisor vital signs monitor to ensure animal safety and to evaluate the anesthesia level. An adjustable water-circulating heating pad was used to keep the body temperature stable. The 2D matrix array was directly facing the isocenter of the animals.
During the iRAI imaging, the 2D matrix array was held by a homemade mechanical arm, which provided four degrees of freedom. The arm was directly attached to a mobile cart, which carried all the electronic devices, shown in Fig.. To locate the targeted area in the central axis of the field of view, the geometry center of the 2D matrix array was set 4 cm above the isocenter.
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