Reclaiming Youth – How Scientists Are Getting Around Muscle Aging — A team of researchers at iMM |
Scientists at the Instituto de Medicina Molecular João Lobo Antunes in Portugal have found a way to stimulate muscle regeneration in aged mice by modulating the function of immune cells known as macrophages, using a protein called MANF.
In their research, they discovered a protein that manages the function of a certain group of immune cells known as macrophages. It enhances their ability to remove residue in the muscle undergoing regeneration. “During regeneration, the macrophages are responsible for clearing the dead cells from the muscle after injury, which is a normal step of the process of muscle regeneration. Macrophages act like a cellular vacuum cleaner, cleaning the “dirt” from the muscle,” adds Joana Neves.
On the implications of the study for regenerative medicine and aging, Pedro Sousa-Victor, co-leader of the study and also a group leader at iMM, says: “A central promise of regenerative medicine is the ability to repair aged or diseased organs using stem cells. This approach will likely become an effective strategy for organ rejuvenation, holding the potential to increase human health span by delaying age-related diseases.
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