An analysis supports a hypothesis that laxative use may change the gut microbiome, the researchers say.
The study adjusted for factors that might influence the outcome of the analysis, such as age, diseases, family history of dementia and more. The analysis showed that, over about a 10-year period, 1.3 percent of the participants who regularly used laxatives were diagnosed with dementia, compared with 0.4 percent who didn’t regularly use laxatives. Overall, people who used laxatives regularly were 51 percent more likely to develop dementia than their counterparts.
Researchers write that their analysis supports a hypothesis that laxative use may change the gut microbiome, affecting gut nerves’ signaling ability or possibly producing toxic substances that affect the brain. The research did not show that laxatives caused dementia, but the association is cause for more research, the scientists write.
. “If our findings are confirmed, medical professionals could encourage people to treat constipation by making lifestyle changes such as drinking more water, increasing dietary fiber and adding more activity into their daily lives.”
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