Repeated Stress Can Accelerate Aging of the Eye

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Repeated Stress Can Accelerate Aging of the Eye
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Stress-induced retinal aging produces symptoms similar to those that occur naturally with aging. New research from the University of California, Irvine, indicates that aging plays a significant role in the death of retinal ganglion cells in glaucoma and that new treatment methods for glaucoma patie

Glaucoma is a group of eye diseases that can cause damage to the optic nerve and result in vision loss. It is often caused by an increase in pressure within the eye, which can damage the nerve fibers of the optic nerve.New research from the

Aging is a universal process that affects all cells in an organism. In the eye, it is a major risk factor for a group of neuropathies called glaucoma. Because of the increase in aging populations worldwide, current estimates show that the number of people with glaucoma will increase to over 110 million in 2040.

“Our work emphasizes the importance of early diagnosis and prevention as well as age-specific management of age-related diseases, including glaucoma,” said Skowronska-Krawczyk. “The epigenetic changes we observed suggest that changes on the chromatin level are acquired in an accumulative way, following several instances of stress. This provides us with a window of opportunity for the prevention of vision loss, if and when the disease is recognized early.

“Our work shows that even moderate hydrostatic IOP elevation results in retinal ganglion cell loss and corresponding visual defects when performed on aged animals,” said Skowronska-Krawczyk. “We are continuing to work to understand the mechanism of accumulative changes in aging in order to find potential targets for therapeutics. We are also testing different approaches to prevent the accelerated aging process resulting from stress.

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