Persistent high blood pressure—or hypertension—can increase the risk of a number of serious and potentially life-threatening health conditions, such as heart disease, heart attacks and strokes.
. The study benefitted from access to the world's largest collection of human kidney samples collected after surgery or kidney biopsy conducted before transplantation, known as the Human Kidney Tissue Resource, at The University of Manchester.
They identified hundreds of kidney genes responsible for changes in blood pressure and found an enzyme called glutamyl aminopeptidase, or ENPEP, to be one of the strongest and most persuasive genes associated with blood pressure. The Manchester-led research team instead found that increasing levels of ENPEP in the kidney could have the desired effect of lowering blood pressure.
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