Researchers develop a new multi-omics microsampling method for complete health profiling NaturePortfolio StanfordMed Multiomics Microsampling HealthProfiling
By Neha MathurJan 26 2023Reviewed by Aimee Molineux In a recent study published in Nature Biomedical Engineering, researchers developed a multi-omics-based microsampling workflow for profiling proteins, metabolites, lipids, and specific cytokines and hormones, i.e., multiple analytes, in a single blood sample of 10 μl .
Furthermore, they require 10 to 50 ml of venous blood, limiting frequent collections, which, in turn, hinders the high-resolution analysis of biological processes that go on inside the body over minutes or hours. Lastly, high sample processing costs could be a reason for reluctance in people to participate in large-scale studies in remote areas.
About the study In the present study, researchers described two case studies to demonstrate the analytical capabilities of the multi-omics microsampling workflow in capturing and analyzing thousands of metabolites, lipids, cytokines, and proteins in 10 μl of blood. They used a solid matrix-based device, Mitra, to collect fixed blood volumes.
In the first case study, they assessed response to a complex dietary intervention, i.e., Ensure shake, to discover inflammatory and metabolic responses at an individual level. They screened 28 individuals with diverse backgrounds to develop six metabolic response metrics. Nevertheless, the presented method could be valuable in research and large-scale stability studies, given that the analytes remain stable over time and with varying temperatures before their quantification. Most analytes, especially proteins, remained stable, while lipids were the least stable analytes. Some issues could arise with relatively unstable molecules.
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