Researchers develop novel DNA biosensor for early diagnosis of cervical cancer

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Researchers develop novel DNA biosensor for early diagnosis of cervical cancer
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Molybdenum disulfide (MoS2) has recently garnered attention among materials science researchers owing to its ability to form two-dimensional nanosheets like graphene. The nanosheets are created by the stacking of S–Mo–S layers interacting via Van der Waals interactions.

The researcher duo prepared the novel electrode surface for probing DNA chemisorption by enabling chemical conjugation between two

: acyl bonds on the surfaces of functionalized nano-onions and amine groups present on the modified MoSCyclic voltammetry experiments revealed that a 1:1 composite electrode had an improved rectangular shape compared to that of an MoSnanosheet electrode.

Notably, the target DNAs produced from HPV-16 and HPV-18 Siha and Hela cancer cell lines were detected by the proposed sensor effectively and with high specificity. Consequently, MoSnanosheets with improved electrical conductivity facilitated by complexation with nano-onions provides a suitable platform for developing effective and efficient electrochemical biosensors for the early diagnosis of a wide variety of ailments, including cervical cancer.

Furthermore, combining nano-onions or nanodiamonds with different organic biomaterials can facilitate chemical functionality, electron transfer conductivity, light absorption, and more. These, in turn, can lead to innovative disease sensing, targetedYoungjun Kim et al, A graphitic nano-onion/molybdenum disulfide nanosheet composite as a platform for HPV-associated cancer-detecting DNA biosensors,

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