The first mapping of the heart's crucial ion channels reveals a surprisingly extensive network of proteins. This understanding is the first step towards more precise treatment for patients with cardiac arrhythmias.
For every heartbeat, a complex interplay is required. The fundamental components are the electrical currents that control theDelving deeper into how these electrical currents cause the heart to pump, we encounter the cleverly designed. Ion channels are small pathways in the heart that facilitate and regulate the electrical currents controlling the heart's contractions.
of the 13 most important ion channels in the heart. The study's leader is Professor MSO Alicia Lundby from the Biomedical Institute. The work is published in the journal"There are more than 800 proteins in the overall network. We have created a map of the proteins that are part of the ion channel network," says Alicia Lundby."I was truly surprised by the number of proteins in the networks of the ion channels we have studied.
"Antibodies are molecules that can recognize and bind proteins with high specificity. We used antibodies that specifically bind to the ion channels found in the heart. You can think of the antibody as a sort of molecular fishing rod used to catch the ion channels and their protein networks from the tissue," explains Lundby.mass spectrometry"Mapping the ion channel networks was a significant effort.
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