Three large studies link past SARS-CoV-2 infection to new-onset autoimmune disease, but it is not yet clear what drives this relationship.
, a rheumatologist at Brigham and Women's Hospital in Boston."There's a fine line between appropriately clearing an infection and the body overreacting and setting off a cascade where the immune system is chronically overactive that can manifest as an autoimmune disease," he told Medscape.It takes the immune system a week or two to develop antigen-specific antibodies to a new pathogen.
"If you have a virus that causes hyperinflammation plus organ damage, that is a recipe for disaster," Sharma said."It's a recipe for autoantibodies and autoreactive T cells that down the road can cause problems, especially in people whose immune system is trained in such a way to cause self-reactivity," she added.
. And while long COVID can last for a year or longer, data suggest that symptoms do eventually resolve for most people. What is not clear is why acute autoimmunity triggered by COVID-19 can become a chronic condition in certain patients., a professor of immunology and rheumatology at Stanford University, California, says that people who develop autoimmune disease after SARS-CoV-2 infection may have already been predisposed toward autoimmunity.
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