Researchers uncover how breastcancer cells become resistant to therapy BCMHouston PNASNews
"Working with a mouse model of human ER+ breast cancer, we were surprised to find that over-expressing 14-3-3τ in these tumors led to all thebecoming ER-negative ," said Lin, a member of the Dan L Duncan Comprehensive Cancer Center."I still remember the day I saw the data. The change was dramatic—all the tumors had lost their ER."
In the lab spheroid model the team found that once 14-3-3τ is over-expressed in cancer cells under the right conditions, the cells will increase their levels of ERα36 and this is followed by ER loss. , which includes fibroblasts and immune cells that are part of the tumor mass and cross talk with the cancer cells, also are essential for the progression from ER+ to ER-."breast cancer cells
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