Digital twin model simulates real-life alcohol consumption patterns and links them to long-term biomarkers, aiding eHealth strategies to curb dangerous drinking habits. The model captures complex physiological interactions between food, beverages, and alcohol metabolism.
By Vijay Kumar MalesuMay 9 2024Reviewed by Benedette Cuffari, M.Sc. In a recent study published in the journal npj Digital Medicine , researchers developed a digital twin model that simulates real-life alcohol consumption and links it to long-term clinical biomarkers, thereby enhancing eHealth strategies to reduce dangerous drinking habits.
EHealth applications, including tools like estimated blood alcohol concentration calculators, have shown promise in reducing excessive drinking. However, models like the Widmark equation, which estimates blood alcohol levels, fail to capture the complexities of real-life drinking patterns, including interactions with different drink types and food.
The model intricately details the dynamics of gastric emptying by incorporating variables like drink volume and caloric content, both of which affect the stomach's volume and rate of emptying. These dynamics are influenced by the caloric content of liquids and the presence of solid food, with specific equations modeling how calories from food slow gastric emptying.
a Short overview of the physiological process that the model describes. Ethanol enters the body via the stomach, where already a small amount can enter plasma. Via the stomach emptying, the ethanol enters the intestine. Here, most of the ethanol is taken up via absorption. Most of the ethanol is metabolized in the liver, and a small amount is excreted via renal pathways.
The model captures this phenomenon by depicting consistent emptying rates across different caloric types but varied rates based on total caloric content. This gastric emptying behavior, irrespective of caloric density, is effectively modeled, thus offering a detailed understanding of the involved physiological processes.
Binge Drinking Blood Chronic Ethanol Food Liver Medicine Metabolism Research Stomach
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