A Review published in Cancer Cell International summarizes the history and structure of regulators of G protein signaling (RGS), its role in cancer, molecular mechanisms, and its implications on novel targeted drug development and cancer therapy.
Table 2 Summary of mechanisms underlying RGS proteins in cancers
In summary, RGS proteins act as important mediators in cancers by regulating cancer cell functions and improper expression of RGS proteins are closely associated with cancer initiation and progression.Despite that we have learned much from the findings of past work focused on several RGS proteins, overall efforts in targeting RGS proteins are woefully incomplete.
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