RNA drugs lower lipoprotein(a) and genetically driven cholesterol - Cormac_Sheridan
-Me and 2′-deoxy-2′-fluoro modified siRNA containing phosphorothioate linkages in its backbone to confer stability and conjugated to GalNAc to increase liver uptake. Olpasiran demonstrated up to 97% lipoprotein reductions in participants with 70–199 nmol lat the outset, the drop was up to 91%.
that Ference and colleagues conducted has already provided insights into its likely outcome. The main finding is that a very large absolute reduction in Lp — of the order of 100 mg dl— is needed to achieve a meaningful reduction in risk. If a patient’s Lp levels are low to begin with, cutting them even by as much as 80% is unlikely to be useful.
Silence Therapeutics appears to have similar advantages to Amgen. As a small company, it will not be in a position to fund and run a cardiovascular outcomes study itself, so the London-based company is seeking a partner to take the SLN360 program through the later stages of development. “If people are interested in cardiovascular risk and in treating cardiovascular disease, they have to be in this area,” says Giles Campion, chief medical officer at the company.
“If people are interested in cardiovascular risk and in treating cardiovascular disease, they have to be in this area” It will be at least three years before any Lp-lowering therapies can reach the market. Clinical guidelines on managing Lp-associated risk in the absence of targeted therapies will become available shortly, says Ference. “There is a huge educational effort required,” says Campion. And now that effective therapies are on the horizon , the question of whether to screen for high Lp is becoming increasingly relevant.
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