As the respiratory illness helps to fuel a ‘tripledemic’, Pfizer and GSK race to get jabs approved.
looks back at how vaccines for RSV emerged, and ahead to how they are about to change the public-health landscape.Efforts to develop an RSV vaccine were set back substantially after a particularly notable failure in the 1960s. Researchers had developed a vaccine containing RSV particles that were chemically inactivated so that the virus couldn’t replicate. But when they tested the shot in infants in a clinical trial, it ended in tragedy: two babies died.
The failure halted efforts to develop an RSV vaccine, as scientists worked to understand what had happened.Rather than continue trying to make a vaccine from inactivated virus, researchers attempted to make, in which an isolated component of the virus, such as a surface protein, is used to trigger a protective immune response. A major breakthrough came when scientists, including McLellan, characterized the different conformations of protein F, a molecule found on the surface of RSV.
McLellan and a number of collaborators eventually characterized the structure of the prefusion form and then worked out how to stabilize it
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