The EC has granted marketing authorization for ruxolitinib cream, a breakthrough treatment for nonsegmental vitiligo with facial involvement in people 12 years of age and older. DermTwitter
), assessing the efficacy and safety of ruxolitinib vs vehicle in more than 600 people with nonsegmental vitiligo, age 12 and older.According to drugmaker Incyte, the study drug resulted in significant improvements in facial and total body repigmentation vs vehicle, which was demonstrated by the number of patients reaching the facial and total body Vitiligo Area Scoring Index endpoints at week 24 vs vehicle and in an open-label extension at week 52.
"At Week 52, approximately one in two of [ruxolitinib]-treated patients achieved F-VASI75," the company states in a There were no serious treatment-related adverse events related to ruxolitinib cream. The most common adverse reaction wasIn patients with nonsegmental vitiligo with facial involvement, ruxolitinib cream is approved for topical use twice a day to depigmented areas up to a maximum of 10% body surface area.Overactivity of the JAK signaling pathway is thought to drive inflammation involved in the progression of vitiligo.
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