Anticipating & managing drug interactions: Pharmacokinetics of long-acting HIV treatment + prevention formulations. MedTwitter medicalpodcast medicalresearch HIV
that can be used subcutaneously every 6 months in certain situations. As you see these new longer-acting drugs emerging, what are the issues and challenges you see, especially in terms of using these medications but in the realm of drug-drug interactions as well?I think this is the future, Mike.
I think the major strategy that's being used, however, is to reserve long-acting delivery for drugs that already are felt to have essentially no or exceedingly rare adverse effects in humans. Sometimes it's hard to predict that, but our preclinical and early clinical testing is getting better.
As predicted, our time is rapidly flying by. I want to finish with a final question to you about what do you see developing in the next 5-10 years? If you had to give your crystal ball analysis, what do you expect we'll be doing in the way of antiretroviral therapy 7 years from now?I think 7 years from now, the majority of HIV-infected individuals are going to be treated with long-acting agents.
There are some amazing new ways of delivering long-acting antiretrovirals in development: for example,that have microneedles that dissolve under the skin but leave behind a nanoformulated depot for long-acting delivery of drugs like cabotegravir. I think we're going to be seeing more of those kinds of approaches to drug delivery. Approaches we would have considered to be science fiction just a few years ago are going to be science fact in the next 5-7 years.I think you're exactly right.
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