Salford rape: New DNA sparks appeal hope for 2003 conviction

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Salford rape: New DNA sparks appeal hope for 2003 conviction
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New DNA sparks appeal hope for 2003 rape conviction

A man who spent 17 years in jail for a rape he says he did not commit has had his convictions referred to the Court of Appeal following new DNA evidence.The now 57-year-old said he "finally has the chance to prove his innocence".

Following a trial at Manchester Crown Court, he was convicted by majority verdict in February 2004 and jailed for life. CCRC chairwoman Helen Pitcher said: "The new results raise concerns about the safety of these serious convictions. It is now for the Court of Appeal to decide whether they should be quashed."In the ever-changing world of forensic science, it is crucial an independent body can undertake these enquiries and send cases of concern back to court.

"I only have one life and so far 20 years of it has been stolen from me. Yesterday I turned 57 years old. How much longer will it take?"

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Walking pace, handgrip strength, age, APOE genotypes, and new-onset dementia: the UK Biobank prospective cohort study - Alzheimer's Research & TherapyWalking pace, handgrip strength, age, APOE genotypes, and new-onset dementia: the UK Biobank prospective cohort study - Alzheimer's Research & TherapyBackground The independent and additive associations of walking pace and grip strength on dementia risk and the potential modifying effects of age, APOE phenotypes, and other dementia risk factors on the walking pace and dementia relationships demand further clarification. We aimed to investigate the independent and additive relationships of walking pace and handgrip strength on the risk of new-onset dementia and examine the potentially modifying effects of age, APOE phenotypes, lifestyle factors, and family history of dementia in the relationships. Methods A total of 495,700 participants from the UK Biobank, who were free of dementia at baseline, were included in this study. Walking pace was self-defined as slow, average, or brisk. Handgrip strength was assessed by dynamometer and was divided into sex-specific quartiles. The APOE genotypes were determined by a combination variant of rs429358 and rs7412. Other dementia risk factors, including education, physical activity, hypertension, depression, diabetes, and family history of dementia, were also collected. The primary outcome was new-onset all-cause dementia. Results Over a median follow-up duration of 12.0 years, 3986 (0.8%) participants developed new-onset all-cause dementia. Compared with those with slow walking pace, participants with average (HR, 0.61; 95%CI: 0.55–0.68) or brisk (HR, 0.59; 95%CI: 0.52–0.67) walking pace had a significantly lower risk of new-onset all-cause dementia. Moreover, compared with those with both slow walking pace and lower handgrip strength (the first quartile), the lowest risk of new-onset all-cause dementia was observed in participants with both average or brisk walking pace and higher handgrip strength (the 2–4 quartiles) (HR, 0.45; 95%CI: 0.40–0.52). Notably, the negative relationship between walking pace and the risk of new-onset all-cause dementia was significantly reduced as APOE ε4 dosage increased (APOE ε4 dosages = 0 or 1: brisk vs. slow: HR, 0.55; 95%CI: 0.48–0.63; vs. A
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