SARS-CoV-2 Omicron's newest subvariant BQ.1.1 shows extraordinary immune evasion potential against vaccine sera biorxivpreprint BIDMChealth SARSCoV2 COVID19 Omicron Subvariant ImmuneEvasion Vaccine VaccineSera
By Neha MathurNov 4 2022Reviewed by Aimee Molineux In a recent study posted to the bioRxiv* preprint server, researchers pursued immunological evidence of why BQ.1.1 prevalence swiftly increased in areas where Omicron BA.5 was dominant in the United States .
About the study In the present study, researchers assessed nAb titers in 16 individuals who were vaccinated and boosted with the monovalent mRNA BNT162b2 vaccine in 2021. Next, they evaluated nAb titers in 15 individuals who received the monovalent mRNA boosters in 2022. Additionally, 18 bivalent mRNA booster recipients, most of whom received three vaccine doses, although some had also received two or four COVID-19 vaccine doses.
Compared to the uninfected 2021 cohort, most were likely infected in these cohorts, although the documented rates for SARS-CoV-2 Omicron infections were as low as 33%. Also, WA1/2020 and Omicron nAb titers were higher in the two 2022 cohorts even before boosting. After boosting, their median NAb titers to WA1/2020, BA.5, BF.7, BA.2.75.2, and BQ.1.1 were 40,515, 3693, 2399, 883, and 508, respectively.
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