SARS-CoV-2 prime and booster vaccinations found to improve pregnancy and birth outcomes isbsci medrxivpreprint SARSCoV2 COVID19 Vaccination Booster Pregnancy
By Pooja Toshniwal PahariaAug 19 2022Reviewed by Aimee Molineux In a recent study posted to the medRxiv* preprint server, researchers evaluated the impact of coronavirus disease 2019 prime vaccination and booster vaccination during pregnancy on maternal and fetal health outcomes.
The multicenter study was conducted on women aged 18 to 45 who delivered at PJSH sites in California, Alaska, Oregon, Montana, Texas, Washington, and New Mexico between 26 January 2021 and 11 July 2022. Data were obtained from PJSH electronic health records of all participants with singleton pregnancies and delivery ≥20 weeks post-gestation.
Other maternal health outcomes included rates of gestational hypertension, gestational diabetes, and preeclampsia. The secondary birth outcomes assessed were preterm births, stillbirths, gestational age at delivery, rates of low birth weight , and very low birth weight . COVID-19 was diagnosed based on polymerase chain reaction reports.
The vaccinated cohort showed a significantly lower likelihood of requiring vasopressors and oxygen supplementation than the unvaccinated matched cohort. Significantly lower rates of stillbirths, very low birth weight, and preterm births were reported for vaccinated individuals compared to the unvaccinated cohort. Three COVID-19-associated maternal deaths were reported, all of which were among unvaccinated individuals.
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