Researchers use stem cells from mice to form embryo-like structures with intestinal tract, beginnings of a brain, and a beating heart
Researchers have created the world’s first “synthetic embryos” in a groundbreaking feat that bypassed the need for sperm, eggs and fertilisation.found that stem cells from mice could be made to self-assemble into early embryo-like structures with an intestinal tract, the beginnings of a brain, and a beating heart.
“Remarkably, we show that embryonic stem cells generate whole synthetic embryos, meaning this includes the placenta and yolk sac surrounding the embryo,” said Prof Jacob Hanna, who led the effort. “We are truly excited about this work and its implications.” The work isLast year, the same team described how they had built a mechanical womb that enabled natural mouse embryos tofor several days.
Hanna said synthetic embryos were not “real” embryos and did not have the potential to develop into live animals, or at least they hadn’t when they had been transplanted into the wombs of female mice. He has founded a company calledthat aims to grow human synthetic embryos to provide tissues and cells for medical conditions.
“Synthetic human embryos are not an immediate prospect. We know less about human embryos than mouse embryos and the inefficiency of the mouse synthetic embryos suggests that translating the findings to human requires further development,” Briscoe said.
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