The sometimes-pathogenic bacteria Staphylococcus aureus has a long and intimate relationship with people, one that helps it fend off our immune response. Staphylococcus aureus is a common bacterium that is harmless, for the most part, posing no threat to humans with whom they coexist. However, on
bacteria are generally harmless, but can sometimes become an opportunistic pathogen. Past efforts to develop a vaccine have proved fruitless. Credit: NIAIDhas a long and intimate relationship with people, one that helps it fend off our immune response.is a common bacterium that is harmless, for the most part, posing no threat to humans with whom they coexist. However, on occasion, it can develop into an opportunistic pathogen, causing food poisoning or skin and bloodstream infections.
, a type of staph bacteria that has become increasingly resistant to the antibiotics typically used to treat ordinary staph infections. MRSA has spread to become the primary source of infections acquired within hospitals and other health care settings, such as nursing homes. In fact, astudy published in 2022 estimated that bacterial antimicrobial resistance resulted in tens of millions of infections and 1.2 million deaths worldwide in 2019, with MRSA as the primary driver.
With first author Chih-Ming Tsai, PhD, a project scientist in his lab, and others, Liu hypothesized that while laboratory mice with no previous exposure torespond well to potential vaccines because they are entirely new, human versions do not work because“Staph vaccines appear so easy to make in laboratory mice because they rarely see, but humans are exposed to staph beginning in the first weeks of life and, in order to coexist, staph appears to have developed many strategies to render...
When researchers tried mixing human IsdB antibodies with protective antibodies made from the vaccine, the latter stopped working. “We surmised that if we could vaccinate only against the protective component of IsdB, we might be able to prevent suppression by bad immune response memory,” said Tsai.
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