The Y chromosome carries a gene called SRY, which turns on male genes on other chromosomes.
that was only present in the males was discovered after extensive investigation. On chromosome 3, this duplicated region was situated before the Sox9 gene.
In the Amami spiny rat, the Enh14 region is duplicated. The two copies of Enh14 act in concert to upregulate Sox9, which causes the differentiation of the testes.The researchers discovered that the Amami spiny rats' sequence duplication constituted a new regulatory element that elevated Sox9 in the absence of Sry. They were able to map its position on the chromosomes in relation to Sox9, and it was shown to be similar to Enh14, a possible Sox9 enhancer in mice.
They believe that the two copies of Enh14 work together to increase the expression of Sox9. When they inserted the sequence into the genomes of mice using gene editing techniques, female This study is the first discovery of a male-specific genetic element directly related to a sex-determining mechanism in mammals that is independent of Sry. Future research will concentrate on determining the precise method by which Enh14 functions, as well as other components of this novel system.
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