Death cap mushrooms, responsible for about 90% of mushroom poisonings, may have met their match in an inoffensive green dye.
. Researchers used CRISPR to create a pool of human cells with different mutations to see whether any proved resistant to alpha-amanitin, the toxic component in death caps .
When cells lacked a protein called STT3B they were able to resist the toxic effect of alpha-amanitin, which meant this protein was important to the way the toxin killed cells. After scouring a database of U.S Food and Drug Administration–approved drugs, researchers found a that dye called indocyanine green, typically used for medical imaging, blocked this protein. When given to mice 4 hours after poisoning, it increased survival rates and protected them from the toxin by halting liver damage.
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