Developing a new, light-activated method to produce the molecule opens doors for future biomedical applications.
Scientists from the Department of Energy's SLAC National Accelerator Laboratory have gained valuable insights into producing nitroxide, a molecule with potential applications in the biomedical field. While nitric oxide has long been on researchers' radar for its significant physiological effects, its lesser-known cousin, nitroxide , has remained largely unexplored.
"Although this research is fundamental in nature, the hope is that other researchers can take what we learn from this molecule and build therapeutic technologies off of it by optimizing similar molecules for medicine," said SLAC scientist and collaborator Leland Gee."The idea would be to get a molecule that releases HNO in the body where it is needed and shine light on it to release it for the therapeutic properties.
This work helps build an understanding of which properties to monitor in future experiments at LCLS, where scientists will be able to take real-time snapshots of the nitroxide photogeneration process. "Although we are still far away from using light on these molecules to treat serious cardiovascular conditions, fundamental insights in these molecules lay substantial groundwork for applied research in the future," Gee said."This may lead to entirely new ways to use light to treat cardiovascular conditions, microbial infections, cancer and other health conditions."Chicago
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