Findings from experiments on cells and mice could lead to the creation of a new class of anticancer drugs. Researchers from the National Institutes of Health and Massachusetts General Hospital in Boston have discovered a promising new strategy to combat liver cancer, which may pave the way for a no
in Boston have discovered a promising new strategy to combat liver cancer, which may pave the way for a novel class of anticancer medications. Through a series of cell and mouse experiments, the scientists observed that an enzyme generated in liver cancer cells has the ability to transform certain compounds into anticancer agents, effectively destroying cancer cells and lessening the severity of the disease in animals.
Hall, Nabeel Bardeesy, Ph.D., a liver cancer specialist at Massachusetts General Hospital and their colleagues reported their results in the journalThe finding stems from a collaboration between Massachusetts General Hospital and NCATS researchers. Bardeesy was originally studying cholangiocarcinoma, a type of liver cancer that affects the bile duct. The cancer is characterized by mutations in the IDH1 enzyme.
The researchers examined other databases of drug screening results in compound and drug libraries to match drug activity with SULT1A1 activity. They also looked at a large National Cancer Institute database of anticancer compounds for additional possibilities to test for their activity with the enzyme.
The scientists suggest these findings have broader implications for developing new anticancer drugs. “We think these molecules have the potential to be an untapped class of anticancer drugs that depend on SULT1A1 for their activity against tumors,” Bardeesy said.
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