Ileana Piña interviews Zachary Cox, PharmD, about the DICTATE-AHF trial on the initiation of the SGLT2 inhibitor, dapagliflozin, early in acute heart failure decompensation.
Diuretic Efficiency and Safety FindingsYour goal was not a diuretic, rather your goal was the diuresis however you got there. Tell us the key findings.The primary efficacy outcome that we looked at was diuretic efficiency.
Relative to the efficacy, we found for the primary outcome of diuretic efficiency, this was in a P0 logistic regression model adjusted for baseline weight. The odds ratio favored dapagliflozin, at 0.65, but the 95% confidence interval upper limit exceeded 1. It was 1.01 with avalue of 0.06, so we just missed statistical significance for the primary outcome of diuretic efficiency.There were not many patients when you put it into the larger context.
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