Single-dose smallpox vaccine could be effective against mpox medrxivpreprint UKHSA Smallpox Mpox Vaccine SingleDoseVaccination
By Tarun Sai LomteDec 19 2022Reviewed by Aimee Molineux In a recent study posted to medRxiv* preprint server, researchers estimated the efficacy of a single-dose Modified Vaccinia Ankara-Bavaria Nordic vaccine against mpox in gay, bisexual, and other men who have sex with men .
About the study In the present observational study, researchers assessed the effectiveness of a single MVA-BN vaccine dose against symptomatic MPX among GBMSM in England. They implemented a case coverage or screening method comparing vaccination rates among cases with those in the population. Weekly vaccination rates among GBMSM individuals and the estimate of the GBMSM denominator were used to determine coverage.
Findings Weekly vaccination coverage increased to 47% by early October 2022, with most of the doses administered by August 22, 2022. Overall, 1,102 MPX cases completed questionnaires. Fifty-two cases were excluded from the investigation since they were female or heterosexual males. Of the cases, 460 had an index date of July 4, 2022, or later. Ninety-seven cases lacked an exact date of vaccination and were excluded; thus, 363 cases were considered for analysis.
Conclusions The researchers estimated the effectiveness of one dose of the MVA-BN vaccine against symptomatic MPX to be 78% after a minimum of two weeks post-vaccination. There was no evidence of protection against disease in the 13 days post-vaccination. These estimates were concordant with the Israeli study, which found 79% efficacy of single-dose MVA-BN vaccine in GBMSM individuals.
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