Finding that clearance of fluid in mice brains is lower in sleep and anaesthesia runs counter to dominant view in neuroscience
The researchers predict that the findings in mice will extend to humans as sleep is a core need shared by all mammals.The researchers predict that the findings in mice will extend to humans as sleep is a core need shared by all mammals.
“It sounded like a Nobel prize-winning idea,” said Prof Nick Franks, professor of biophysics and anaesthetics at Imperial College London, and co-lead of the study. The study showed that the clearance of the dye was reduced by about 30% in sleeping mice, and 50% in mice that were under anaesthetic, compared with mice that were kept awake.
The findings have relevance for dementia research due to the increasing evidence of a link between poor sleep and Alzheimer’s risk. It has not been clear whether lack of sleep might cause Alzheimer’s, or whether it is simply an early symptom. Some had hypothesised that without enough sleep, the brain may not be able to clear toxins effectively, but the latest research raises doubts about the plausibility of this explanation.
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