A research team led by Shi Chaowei from the University of Science and Technology of China (USTC) of the Chinese Academy of Sciences (CAS) has adapted the fluoride ion channel protein Fluc-Ec1 combined with deuterium substitution and 19F labeling methods, paving a new path for membrane protein nuclear magnetic resonance (NMR) research.
but also observes their dynamic characteristics. These insights are invaluable for understanding the functional mechanisms of large biomolecules such as proteins. With the advancement of high-speed magic-angle spinning technology, the resolution of solid-state NMR spectroscopy was significantly improved. Theoretically, it surpasses the molecular weight limitations of liquid NMR, gradually being applied to the study of dynamic conformations of complex biomolecular systems.
However, the challenges of low signal strength and resolution remain, limiting its widespread application in solid-state biomolecular NMR research. Hydrogen and , due to their high gyromagnetic ratios and strong NMR signals, emerge as ideal candidates for NMR observation., has a unique structure and demonstrates high selectivity towards fluoride ions. The researchers investigated the Fluc-Ec1 conformation in phospholipid bilayers and introduced 4--l-phenylalanine into the vestibule space by the codon extension method.
Australia Latest News, Australia Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Ex-Met Zack Wheeler haunts his old team with solid outing for PhilliesZack Wheeler wasn’t showing much Brotherly Love for his former team Saturday.
Read more »
Penn State defense stifles Iowa; Drew Allar delivers solid performance in annual White Out gameThe sophomore completed 25 of 37 pass attempts for 166 yards and three touchdowns in a battle of ranked foes in front of a crowd of 110,830.
Read more »
'A Haunting in Venice' Conjures Up a Solid Performance at the Global Box OfficeThe sequel sees Kenneth Branagh return to his role as Detective Hercule Poirot.
Read more »
‘Solid as a rock’: First asteroid sample collected in space by NASA touches down on EarthThe first asteroid sample collected in space by NASA has been successfully returned to Earth.
Read more »
'City of Wind' Review: Tradition & Modernity Clash in Coming-of-Age DramaThis solid feature debut looks at modern Mongolia beyond what Western society imagines it to be.
Read more »
Keychron’s New Lemokey L3 Gaming Keyboard Is A Real WinnerThis solid and customizable Lemokey L3 gaming keyboard from Keychron is a a top-flight gaming keyboard and completely programmable using QMK/VIA.
Read more »