Stillbirths and preterm births significantly lower in COVID vaccinated women COVID19 Coronavirus Pregnancy Respiratory SARSCoV2 medrxivpreprint UniMelb MonashUni MercyHealthAus PeninsulaHealth
Studies have reported that COVID-19 vaccination in pregnant women reduces stillbirths; however, the association between COVID-19 vaccines and premature births is not certain. In addition, most studies on severe acute respiratory syndrome coronavirus 2 vaccination during pregnancy had limitations in their methodologies, such as time-varying exposures and fixed cohort bias.
Data were obtained from 12 public hospitals in Melbourne city of Australia, on births after 20 gestational weeks, between July 1, 2021, and March 31, 2022, under the collaborative maternity and newborn dashboard for the COVID-19 pandemic research project. Planned home births, private hospital births and those not a part of public-funded home birth programs were not included in the analysis.
Related StoriesThe study's primary outcome was the congenital anomaly rate in single infants born after 20 gestational weeks among women who received COVID-19 vaccinations in pregnancy. Secondary pregnancy outcomes included stillbirths, premature births , fetal growth restrictions indicated by fetal birth weight under the third centile, and neonatal intensive care unit admissions were assessed for single infants born after 24 gestational weeks without any congenital anomalies.
Substantial differences were observed in the rates of vaccination by birth region. The aORs of vaccination were lower among women who had been birthed in the Middle East, East Europe, South Europe, Oceania, and Africa. Women who received COVID-19 vaccines during pregnancy were substantially less likely to give birth to infants with significant congenital anomalies in comparison to the unvaccinated women .
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