Nature research paper: Strain-promoted reactions of 1,2,3-cyclohexatriene and its derivatives
. Of these compounds, 1,2,3-cyclohexatriene has been largely overlooked. This strained isomer is substantially higher in energy compared to benzene and, like its relatives benzyne and 1,2-cyclohexadiene, should undergo strain-promoted reactions. However, few experimental studies of 1,2,3-cyclohexatriene are known. We demonstrate that 1,2,3-cyclohexatriene and its derivatives participate in a host of reaction modes including diverse cycloadditions, nucleophilic additions, and σ-bond insertions.
Experimental and computational studies of an unsymmetrical derivative of 1,2,3-cyclohexatriene demonstrate the potential for highly selective reactions of strained trienes despite their high reactivity and short lifetimes. Finally, integration of 1,2,3-cyclohexatrienes into multistep synthetic sequences demonstrates their utility in rapidly assembling topologically and stereochemically complex molecules.
Australia Latest News, Australia Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Ask a Stoner: Why Don't Dispensaries Sell the Same Strain From Different Growers?We're not talking about The Wire here, but territory and sales relationships really matter in retail.
Read more »
FDA simplifies COVID vaccine schedules, withdraws authorization for older COVID-19 vaccines targeting virus' original strainThe FDA is authorizing a second omicron-targeted bivalent COVID-19 booster vaccine for people over 65 or who are immunocompromised, the agency announces.
Read more »
Consensus recommendations on how to assess the quality of surgical interventions - Nature MedicineHow to measure the quality of surgical interventions? The Outcome4Medicine consensus group outlines recommendations for postoperative outcome assessment, with the goal of improving care quality and patient health. ADomenghino UZH_en
Read more »
Institutional review boards need new skills to review data sharing and management plans - Nature MedicineInstitutional review boards need new skills to review data sharing and management plans. Comment from VNRahimzadeh bcmhouston, Kimberley Serpico HarvardChanSPH and Luke Gelinas advarra
Read more »
Integrating a healthcare innovation bootcamp into an international medical conference to democratize innovation learning - Nature BiotechnologyIntegration of an intensive innovation education bootcamp into a large international conference demonstrates statistically significant increases in participant understanding and knowledge of healthcare innovation.
Read more »
Incident type 2 diabetes attributable to suboptimal diet in 184 countries - Nature MedicineModeling analysis from the Global Dietary Database estimated that 70% of new global cases of type 2 diabetes are attributable to suboptimal intake of 11 dietary factors, with substantial differences in dietary risks across world regions and nations.
Read more »