More than 43 years ago, many Chinese residents were vaccinated with the vaccinia virus Tiantan strain (VTT) to protect them from smallpox infection.
A recent Signal Transduction and Targeted Therapy study assessed the level of immunity against smallpox in the aforementioned group of individuals. The level of immunological susceptibility to the mpox virus was also determined.
As of June 21, 2023, around 88,026 mpox cases have been reported across 111 countries. In the UK, the first mpox case was detected on May 6, 2022; subsequently, a rapid transmission of this virus was recorded. The World Health Organization declared mpox disease to be a public health emergency of international concern.
Related StoriesAt present, two smallpox vaccines JYNNEOS and ACAM2000 are used to prevent mpox. These vaccines were approved by the US Food and Drug Administration in 2019 to be used for adults at a higher risk of mpox and smallpox infections. The second group comprised 66 participants between 43 and 53 years of age with a history of smallpox vaccination between 1970 and 1980. The third group included 44 participants whose ages were between 54 and 63 years.
This finding implies that humoral immunity from smallpox vaccination persists in the Chinese population over 43 years of age; however, VTT-specific NAb level declines with age.
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