Study: Common Drug Found Effective Against IBS

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Study: Common Drug Found Effective Against IBS
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An inexpensive medication long used for depression and migraines now has a clinical trial to back up its off-label use for another condition that lowers quality of life: irritable bowel syndrome (IBS). In the study, British researchers found that those taking amitriptyline...

An inexpensive medication long used for depression and migraines now has a clinical trial to back up its off-label use for another condition that lowers quality of life: irritable bowel syndrome .

“IBS has a substantial impact in terms of affecting social activity, ability to work, out-of-pocket expenses and quality of life for sufferers,” Ford said. The new trial included more than 460 people from three regions in the United Kingdom who saw doctors at 55 practices. They were randomized to receive either amitriptyline or a placebo.

Ford said the medication may work well for this condition because it may have pain-modifying effects, as well an effect on bowels.The findings were published online Oct. 16 in The Lancet and presented simultaneously at the United European Gastroenterology conference, in Copenhagen, Denmark. Staller noted there has been some reluctance to prescribe these drugs in the primary care community and even among some gastroenterologists because they carry the stigma of being antidepressants.

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