Study evaluates efficacy of a candidate SARS-CoV-2 subunit vaccine to protect endangered black-footed-ferrets USGS Ferrets Vaccine VaccineCandidate SARSCoV2 COVID19
By Dr. Chinta SidharthanOct 7 2022Reviewed by Aimee Molineux In a recent study published in Viruses, researchers assessed the safety, efficacy, and immunogenicity of a candidate severe acute respiratory syndrome coronavirus 2 subunit vaccine in black-footed ferrets . They investigated the susceptibility of these endangered North American mammals to the virus.
Given the susceptibility of closely related species to SARS-CoV-2, added precautions such as physical distancing, ultraviolet air filtration, and personal protective equipment have been enforced at the BFF breeding facilities to prevent viral exposure. However, such measures are expensive and not sustainable over long periods and hinder the breeding program.
Booster vaccines and sham injections were given to the test and control groups, respectively, three weeks after the first injection. The vaccine doses were 50 µg, based on an earlier SARS-CoV-1 study using Syrian hamsters. The animals were observed daily for signs of morbidity. The mice were then intranasally inoculated with SARS-CoV-2 24 hours after serum transfer and observed for signs of morbidity and weight loss. They were subsequently euthanized, and tissue samples from the lungs, brain, nasal turbinate, spleen, liver, and intestines were collected for histopathological observations.
The mice that received serum from vaccinated and unvaccinated BFFs developed an unexpected acute reaction to an antigen in the ferret serum, compromising the serum transfer and viral challenge study.
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