Study explores cell signaling dysregulation and COVID-19 severity SARSCoV2 COVID19 SevereCOVID CellSignaling
By Bhavana KunkalikarOct 12 2022Reviewed by Aimee Molineux In a recent study published in the Virus Research journal, researchers assessed the impact of dysregulation in cell signaling events on coronavirus disease 2019 severity.
Clinical manifestations of COVID-19 due to dysregulated cell signaling pathways Respiratory symptoms: The most common signs of COVID-19 respiratory problems include hypoxia, pneumonia, lung edema shown as acute lung injury , and acute respiratory disease syndrome , which can typically result in lung failure.
Renal dysfunction: Additionally, COVID-19 has been linked to acute renal damage and kidney function decline . A serious issue with AKI has been identified in hospitalized individuals with severe COVID-19. Although there is no association found with SARS-CoV-2, the viral infection in the kidney is thought to trigger TLR4 mRNA in tubular cells that induce ischemia, tubular necrosis, and inflammation.
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