A new paper examined the retinal data from Parkinson disease patients in attempt to identify disease markers.
By Dr. Liji Thomas, MDAug 24 2023Reviewed by Sophia Coveney The neurodegenerative changes seen in the retina of people suffering from Parkinson disease have been described using cadaveric imaging. However, the corresponding changes in the living eye have not yet been reliably described.
The eye is an outgrowth of the central nervous system and is easily imaged with high-resolution imaging devices. The nervous part of the retina contains dopaminergic cells in the inner plexiform layer and inner nuclear layer . However, a review of ten studies indicated thinning of the macular retinal nerve fiber layer and the ganglion cell-inner plexiform layer . The opposite was true of the INL. The current study thus attempted to identify associations between retinal imaging data and PD, both before and after the diagnosis.
They explored the presence of associations between prevalent PD and retinal thickness. They also estimated the change in risk for PD over time at various retinal thicknesses. In the UK Biobank cohort, of the >50,000 participants, slightly over half were women, with the mean age being 56 years. There were 53 new PD cases. The time to PD diagnosis was ~2,600 days on average.
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