Study finds higher BMI and smoking increased time to conception Fertility Smoking BMI Norway BMCMedicine BristolUni Folkehelseinst HarvardChanSPH UniOslo
By Pooja Toshniwal PahariaApr 10 2023Reviewed by Benedette Cuffari, M.Sc. In a recent study published in the journal BMC Medicine, researchers evaluate the effect of lifestyle behaviors on various fertility and reproductive outcomes.
About the study In the present study, researchers explore the relationships between lifestyle choices and reproductive and fertility outcomes among men and women using a Mendelian randomization approach to account for potential confounding and reverse causation. In addition, summary-level multivariate MR was performed for available study outcomes among the United Kingdom Biobank participants, controlling for educational level and ADHD liability.
The MR approach included multivariate regression analysis, followed by individual-level MR and summary-level Mendelian randomization. For individual-level MR analyses, genetic scores were constructed using genome-wide association studies summary statistics, whereas, for summary-level Mendelian randomization, individual single nucleotide variant effect size data were utilized.
Greater frequency of alcohol intake and binge drinking were both related to having fewer children and greater age at first delivery. Individuals with greater alcohol intake were less likely to require infertility treatment, with odds ratios for alcohol frequency and binge drinking of 0.9 and 0.8, respectively. Greater caffeine intake was related to lower age at first birth among men and a lower likelihood of requiring treatment among women .
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