Study finds mobile antibiotic resistance genes in some probiotic bacteria, raising concerns for public health AntimicrobialResistance Genes Probiotic Eurosurveillanc
By Neha MathurApr 11 2023Reviewed by Benedette Cuffari, M.Sc. In a recent study published in the journal Eurosurveillance, researchers examine antibiotic resistance genes and their mobility in Bifidobacteriales and Lactobacillales species through the use of a unified bioinformatic pipeline to isolate these bacteria from food and probiotic sources.
Identifying potential sources of AMR is important, as it is one of the key threats to the treatment of multiple communicable diseases worldwide in both humans and animals. Excessive antimicrobial use has contributed to a surge in AMR rates worldwide; however, despite mitigation measures to decrease AMU, excessive antibiotic use by animals and humans remains a common practice in many nations.
The researchers downloaded 2,244 samples for 12 probiotic species of interest from the National Center for Biotechnology Information repository. Ten species were also analyzed from non-fermented/fermented foods or probiotic dietary supplements . The bioinformatics pipeline helped the researchers screen genetic data for ARGs and identify those which are mobile.
For example, samples originating from L. lactis and B. animalis were relatively richer in ARGs, while L. paracasei and L. casei strains had no ARGs. Lactobacillus species like L. delbrueckii and L. brevis had relatively less frequent ARGs. Of the 65 ARG-positive B. animalis samples, 62 tet-containing samples showed an association with iMGEs, the interpretation of whose mobility potential is unclear. As a result, the public health implications of these observations remain unclear. Nevertheless, the plasmidome of L. lactis has public health relevance, thereby raising the need for sustained surveillance measures.
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