Study finds molnupiravir well-tolerated, and effective in vaccinated and unvaccinated Antiviral Drug Coronavirus Disease COVID Efficacy molnupiravir medrxivpreprint
By Suchandrima BhowmikJul 27 2022Reviewed by Benedette Cuffari, M.Sc. Molnupiravir is the first orally-available antiviral treatment that can be administered directly to people with mild-to-moderate coronavirus disease 2019 .
Molnupiravir has been shown to effectively reduce the risk of hospitalization and death in treated patients. Furthermore, this treatment has been associated with a higher severe acute respiratory syndrome coronavirus 2 negativity rate following five, ten, and 14 days of treatment. About the study The current study was designed as a randomized, double-blind, and controlled trial that included men or women above 18 years of age with reverse transcription-polymerase chain reaction -confirmed COVID-19.
Molnupiravir was administered at a dose of 800 mg for a total of ten doses twice daily for five days. Study participants were randomly assigned to receive either molnupiravir or the placebo drug after two hours of fasting. The participants were also to fast for one hour after administration of the drug.
Moreover, 57% of the participants were female, and 50% received at least one dose of the COVID-19 vaccine at least 14 days before the study period. The SARS-CoV-2 variants represented among the participants included Alpha, Delta, Omicron, XE, and EU1 variants. Conclusions The current study determined that the efficacy of molnupiravir was retained in both vaccinated and unvaccinated individuals against new SARS-CoV-2 variants. However, larger trials must be carried out to evaluate the efficacy of molnupiravir for a more generalized population. One such trial, the PANORAMIC trial, which is the largest randomized assessment of molnupiravir, is currently being conducted.
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