Researchers reveal age-related differences in nasal epithelial cell responses to SARS-CoV-2, showing variations in cell types and viral dynamics across pediatric, adult, and older adult groups.
By Vijay Kumar MalesuApr 16 2024Reviewed by Susha Cheriyedath, M.Sc. In a recent study published in the journal Nature Microbiology , researchers investigated age-related differences in nasal epithelial cell responses to severe acute respiratory syndrome coronavirus 2 infection across pediatric, adult, and older adult groups.
About the study Participants for the present study were recruited from five major hospital sites in London, United Kingdom , including the Great Ormond Street Hospital National Health Service Foundation Trust, the Royal Free London NHS Foundation Trust, the University College London Hospitals NHS Foundation Trust, and the Whittington Health NHS Trust, between March 2020 and February 2021.
Schematic of method and model used to study SARS-CoV-2 infection of paediatric nasal epithelial cells. One striking finding in pediatric cultures was the increased presence of a specific type of goblet cell, indicating a shift in cell state not observed in adults or older individuals. Despite similar total protein levels of SARS-CoV-2 entry factors among all age groups, messenger RNA levels of these proteins were distinctly higher in pediatric goblet cells, hinting at a different susceptibility to viral infection across ages.
Coronavirus Disease COVID-19 SARS SARS-Cov-2 Coronavirus Fibrosis Gene Hospital Microbiology Mortality Progenitor Cells Protein Research Respiratory RNA Severe Acute Respiratory Severe Acute Respiratory Syndrome Syndrome
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