Study identifies immune signature to predict severe COVID-19 in cardiovascular patients COVID19 cardiovascular immunophenotyping diseaseprogression predictivesignature healthcare research SARSCoV2 pandemic publichealth medrxivpreprint uni_tue
By Tarun Sai LomteMay 1 2023Reviewed by Benedette Cuffari, M.Sc. A recent study posted to medRxiv* preprint server assesses whether immunophenotyping in cardiovascular disease patients could predict coronavirus disease 2019 severity.
COVID-19 and CVD COVID-19 severity is associated with several risk factors, including sex, age, and comorbidities that correlate with immune responses during acute infection. CVD patients are susceptible to more severe outcomes of severe acute respiratory syndrome coronavirus 2 infection, which can subsequently increase the risk of cardiac and pulmonary damage.
CVD patients aged 18 or older with or without COVID-19 were eligible for inclusion. Those with viral/bacterial infections or malignancies were excluded from the study. All subjects underwent clinical/cardiac assessment within 12 hours of hospitalization. Isolated peripheral blood mononuclear cells were stained with an antibody panel and measured with a flow cytometer. Unsupervised data analysis showed 40 clusters of immune cells, including B-cells, cluster of differentiation 4-positive and CD8+ T-cells, natural killer cells, neutrophils, basophils, innate lymphoid cells , dendritic cell subsets, and monocytes.
C-C motif chemokine ligand 2 , C-X-C chemokine ligand 9 , CXCL10, and CXCL11 were highly elevated during COVID-19. IL-6 and IL-8 were also significantly increased in CVD patients with severe COVID-19, whereas CCL17 was less abundant.
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