Study indicates that macrophages that reside in the lymph nodes contribute to the initial Zika virus spread WUSTLmed CellReports lymph lymphnodes zika virus disease infection
By Dr. Chinta SidharthanFeb 20 2023Reviewed by Danielle Ellis, B.Sc. In a recent study published in Cell Reports, researchers mapped Zika virus infections in the lymph nodes to determine how the Zika virus enters from different points in the skin and disseminates through the body.
Monocytes, which are abundant in blood and have access to most tissues in the body, are the primary type of cells infected by the Zika virus and have been studied to understand the movement of the virus. However, the role of the cells within the lymph nodes involved in the early movement of the virus during the dissemination process remains unclear.
Five distinct macrophage populations are found in lymph nodes related to specific immune functions. Macrophages in the nodal sinuses closest to the incoming lymph vessels are called subcapsular sinus macrophages, while those in the nodal sinuses near the exiting lymph vessels are called medullary sinus macrophages.
Furthermore, Siglec1-cre mouse models with CD169+ cells expressing Cre recombinase were crossed with Ifnar1-floxed mice to conditionally delete IFN-I signaling in CD169+ macrophages and create CD169 conditional knockout mice. This mouse model was used to understand the role of lymph node macrophages in disseminating the Zika virus.
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