Study sheds light on immune factors responsible for contrasting SARS-CoV-2 outcomes in humans and white-tailed deer biorxivpreprint IowaStateU covid COVID19 SARSCoV2 deer immune immunology defence
By Bhavana KunkalikarApr 27 2023Reviewed by Lily Ramsey, LLM In a recent study posted in the bioRxiv* preprint server, researchers explored the response of respiratory epithelial cells in deers to severe acute respiratory syndrome coronavirus 2 .
So far, no studies have investigated the innate immune variables accountable for the disparate disease outcomes associated with SARS-CoV-2 in WTD. Results Virus-specific cytopathic effect , like cell rounding, cell detachment/death, and vacuolation, was noted at 48 hpi in Deer-RECs at concentrations over 103 plaque-forming unit /mL, whereas in HRECs, CPE was evident at 72 hpi. Mock-infected controls did not exhibit CPE.
On the other hand, the number of unique DEGs improved throughout SARS-CoV-2 infection in Deer-RECs, from 36 DEGs at six hpi to 135 at 24 hpi and 280 at 48 hp. SARS-CoV-2-inoculated Deer-RECs exhibited a substantial downregulation of the cytokine tumor necrosis factor and chemokines CXCL3 and CXCL8 within the initial 24 hpi. At 24 hpi, the nuclear factor-kappa-B inhibitors NFκ-B-inhibitor alpha or IκB, as well as the negative feedback regulator suppressor of cytokine signaling 3 , were downregulated in Deer-RECs.
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